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| Product Name | Recombinant Escherichia coli O157:H7 (strain TW14359 / EHEC) Translocated intimin receptor Tir |
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| Description | 252-362aa; Extracellular Domain. MW: 27.8kD. Purity >90% as determined by SDS-PAGE. Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Secreted effector protein Tir] |
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| Gene, Accession, CAS # | tir, Accession: WP_001301454.1 |
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| Catalog # | MBS1132098 |
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| Order / More Info | Recombinant Escherichia coli O157:H7 (strain TW14359 / EHEC) Translocated intimin receptor Tir from MYBIOSOURCE INC. |
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| Product Specific References | Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C., Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H., Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K. Miller S.I. Infect. Immun. 77:3713-3721(2009) |
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