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| Antigenic Specificity | Translocation Associated Membrane Protein 2 (TRAM2) (aa 309-325), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TRAM2(Translocation-Associating Membrane Protein 2), also called KIAA0057, is a protein that in humans is encoded by the TRAM2 gene. TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum(ER) membrane. By genomic sequence analysis, Onuchic et al.(1999) mapped the TRAM2 gene to chromosome 6p21.1-p12 near the PKHD1 gene. Upon activation, quiescent hepatic stellate cells proliferate, change morphologically into myofibroblasts, and increase their synthesis of extracellular matrix proteins. Stefanovic et al.(2004) demonstrated that both TRAM2 and collagen type I are upregulated in activated rat and human hepatic stellate cells. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse TRAM2(309-325aa RFIHSQLRHWREYWKEQ), identical to the related rat sequence, and different from the related human sequence by one amino acid. |
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| Other Names | C330003D03Rik |
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| Gene, Accession # | Gene ID: 170829 |
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| Catalog # | ABIN1673495 |
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| Order / More Info | Translocation Associated Membrane Protein 2 (TRAM2) (aa 309-325), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 7584044, 10594243, 14749390 |
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