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| Product Name | Recombinant Mouse E3 ubiquitin-protein ligase Mdm2 |
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| Description | 1-489aa; Full Length. MW: 58.6kD. Purity >90% as determined by SDS-PAGE. E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 pr |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Double minute 2 protein; Oncoprotein Mdm2; p53-binding protein Mdm2] |
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| Gene, Accession, CAS # | Mdm2, Gene ID: 17246, Accession: NP_001275515.1 |
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| Catalog # | MBS964250 |
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| Order / More Info | Recombinant Mouse E3 ubiquitin-protein ligase Mdm2 from MYBIOSOURCE INC. |
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| Product Specific References | Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.Fakharzadeh S.S., Trusko S.P., George D.L.EMBO J. 10:1565-1569(1991) Genomic organization of the mouse double minute 2 gene.Jones S.N., Ansari-Lari M.A., Hancock A.R., Jones W.J., Gibbs R.A., Donehower L.A., Bradley A.Gene 175:209-213(1996) The organization and expression of the mdm2 gene.de Oca Luna R.M., Tabor A.D., Eberspaecher H., Hulboy D.L., Worth L.L., Colman M.S., Finlay C.A., |
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