| 产品详情 |
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| Product Name | Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1) (AA 2-89) protein (GST tag) |
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| Description | The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | POP1|POPDC1|4932434G09Rik |
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| Gene, Accession, CAS # | Gene ID: 10940 |
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| Catalog # | ABIN2745805 |
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| Order / More Info | Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1) (AA 2-89) protein (GST tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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