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| Antigenic Specificity | Discs, Large Homolog 4 (Drosophila) (DLG4) (aa 492-507), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase(MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human PSD95(492-507aa RRVERREWSRLKAKDW), identical to the related rat and mouse sequences. |
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| Other Names | 11|CG1725|CG1730|CPD|DLG|DLG-A|Discs-large|Dlg|Dlg-A|Dlg1|DlgA|Dmel\\CG1725|Drodlg|PSD95|SAP97|anon-EST:Posey93|anon-WO03040301.258|anon-WO03040301.260|anon-WO03040301.268|d. lg.-1|dlg|dlg-1|dlg-A|dlgA|dlgS97|l(1)10Bf|l(1)G0276|l(1)G0342|l(1)G0456|l(1)G19|l(1)L11|l(1)bwn|l(1)d.lg-1|l(1)d.lg.-1|l(1)discs large|l(1)dlg|l(1)dlg-1|l(1)dlg1|l(1)l.pr.-2|l(1)lpr-2|misb|dlgh4|psd95|sap90|sap-90|LLGL1|Dlgh4|PSD-95|SAP90|SAP90A|Sap90|SAP-90|DLG4 |
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| Gene, Accession # | Gene ID: 1742,29495 |
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| Catalog # | ABIN1889243 |
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| Price | |
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| Order / More Info | Discs, Large Homolog 4 (Drosophila) (DLG4) (aa 492-507), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 14642282, 11082065 |
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