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| Antigenic Specificity | Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The AP-2 coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane. Each AP-2 heterotetramer is composed of alpha, beta, my, and sigma protein subunits. The 50 kDa my subunit (AP-2my, AP2M1) is located at the core of the AP-2 complex and mediates interaction between the cargo protein and the clathrin-coated pit. The carboxy-terminal AP2M1 region recognizes the tyrosine-based, endocytotic sorting motif YXXphi found in cargo proteins and helps to bring the cargo protein to the clathrin-coated pit. Non-canonical, tyrosine-based endocytotic sorting signals can also promote interaction between cargo proteins and AP2M1. AP2M1 plays an essential role in molecular signaling as it couples receptor-mediated endocytosis and pathways involving membrane receptors , matrix metalloproteinases , and ion channel proteins. Phosphorylation of specific AP2M1 residues and binding of lipids to this adaptor protein can regulate AP2M1 activity. Phosphorylation of AP2M1 at Thr156 by adaptor-associated kinase 1 (AAK1) stimulates affinity binding of AP2M1 to cargo protein signals.Synonyms: AP50, CLAPM1, mu2 |
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| Immunogen | Recombinant protein of human AP2M1 |
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| Other Names | cb34|Ap2m1|dpy-23|sb:cb34|zgc:55711|zgc:85653|wu:fa97a10|ap2m1|zgc:56643|AP2M1|AP50|CLAPM1|mu2|Ap50|Clapm1|ap2m1-a |
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| Gene, Accession # | Gene ID: 1173,11773,116563 |
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| Catalog # | ABIN1513768 |
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| Price | |
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| Order / More Info | Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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