| 产品详情 |
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| Antigenic Specificity | Cyclin-Dependent Kinase 4 (CDK4) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle.Synonyms: CDK4, CMM3, MGC14458, PSK-J3 |
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| Immunogen | Center-peptide of human CDK4 |
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| Other Names | zgc:153726|CMM3|PSK-J3|Crk3|8-6|CDK4|CDK4/6|CG5072|Cdk4/6|DmCdk4|Dmel\\CG5072|Pk53C|Pk?7|cdk|cdk4|cdk4/6|dCdk4|l(2)05428|l(2)0671|l(2)k06503|l(2)s4639|l(2)sh0671|xcdk4 |
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| Gene, Accession # | Gene ID: 1019,12567,94201 |
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| Catalog # | ABIN1512743 |
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| Price | |
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| Order / More Info | Cyclin-Dependent Kinase 4 (CDK4) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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