| 产品详情 |
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| Product Name | Baculoviral IAP Repeat Containing 2 (BIRC2) protein (His tag) |
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| Description | Multi-functional protein which regulates not only caspases and cancer, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions, as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nod-like receptors (NLRs) and RIG-I like receptors (RLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | Api1|Api2|IAP1|IAP2|MIHB|MIHC|Birc2|HIAP2|MIAP1|MIAP2|RNF49|cIAP1|cIAP2|cIAP-1|cIAP-2|AW107670|ciap-1|API1|Hiap-2|RNF48|c-IAP1|ITA|AW146227|Birc3|HIAP1|mcIAP1|rIAP1|RGD1559914 |
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| Gene, Accession, CAS # | Gene ID: 329 |
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| Catalog # | ABIN2745628 |
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| Order / More Info | Baculoviral IAP Repeat Containing 2 (BIRC2) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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