| 产品详情 |
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| Antigenic Specificity | CD180 Molecule (CD180) |
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| Clone | MHR73 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunoprecipitation (IP),Immunohistochemistry (Frozen Sections) (IHC (fro)),Functional Studies (Func) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody MHR73 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105. |
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| Immunogen | n/a |
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| Other Names | Ly78|CD180|LY64|RP105|F630107B15 |
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| Gene, Accession # | Gene ID: 4064 |
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| Catalog # | ABIN2191954 |
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| Price | |
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| Order / More Info | CD180 Molecule (CD180) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15611257, 9763566 |
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