| 产品详情 |
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| Antigenic Specificity | Parkinson Protein 7 (PARK7) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Parkinsons disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in alpha-synuclein, Parkin, and DJ-1 are linked to PD . alpha-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD . Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator of oxidative stress . Dopamine D2 receptor-mediated functions are greatly impaired in DJ-1 (-/-) mice, resulting in reduced long-term depression . Synonyms: PARK7,DJ-1,DJ1,FLJ27376,FLJ34360,FLJ92274 , |
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| Immunogen | Recombinant protein of human PARK7 |
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| Other Names | dj1|zgc:103725|DJ-1|Dj1|DJ1|CAP1|SP22 |
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| Gene, Accession # | Gene ID: 11315,57320,117287 |
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| Catalog # | ABIN1683845 |
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| Price | |
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| Order / More Info | Parkinson Protein 7 (PARK7) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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