产品名称 DNA polymerase beta Antibody from CREATIVE DIAGNOSTICS
产品货号 CABT-B1673
产品价格 现货询价,电话:010-67529703
产品规格 n/a
产品品牌 CREATIVE DIAGNOSTICS
产品概述
产品详情
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Antigenic SpecificityDNA polymerase beta
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, rat, mouse
Isotypen/a
Formatunconjugated
Sizen/a
Concentrationn/a
ApplicationsWB, IHC
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DescriptionRabbit Anti-Human DNA polymerase beta polyclonal antibody for WB, IHC. DNA polymerase beta (EC 2.7.7.7; UniProt P06746; also known as DNA pol beta, DNA polymerase beta subunit) is encoded by the POLB gene (Gene ID 5423) in human. DNA polymerase beta is involved in DNA recombination and base-excision repair (BER). Upon oxidative DNA damage, Polb translocates to the nucleus, where it associates with AP endonuclease 1 (Apex) to carry out DNA repair. Apex makes a single nick 5? to an abasic site in double-stranded DNA, Polb then inserts the replacement nucleotide(s). Aberrant POLB overexpression results in an increased rate of spontaneous mutagenesis and a highly mutagenic tolerance phenotype. Thirty percent of all tumors are reported to harbor mutations in the POLB gene.
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human DNA polymerase beta.
Other Namesn/a
Gene, Accession #Gene ID: 5423, UniProt: P06746
Catalog #CABT-B1673
Price
Order / More InfoDNA polymerase beta Antibody from CREATIVE DIAGNOSTICS
Product Specific Referencesn/a
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