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| Product Name | Recombinant Human Tumor necrosis factor protein (TNF) (Active) |
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| Description | Purity > 98% as determined by SDS-PAGE and HPLC. MW: 16.9kDa. Partial: 87-233aa. tag-Free. Homo sapiens (Human). Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:22517918, ECO:0000269|PubMed:23396208}.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a,, NTF |
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| Gene, Accession, CAS # | TNF,TNFA,TNFSF2, UniProt: P01375 |
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| Catalog # | RPC26705 |
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| Order / More Info | Recombinant Human Tumor necrosis factor protein (TNF) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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