| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 63.4kDa. Partial: 330-741aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Ribonuclease 4Ribonuclease L; RNase L |
|---|
| Gene, Accession, CAS # | RNASEL, UniProt: Q05823 |
|---|
| Catalog # | RPC22375 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human 2-5A-dependent ribonuclease (RNASEL), partial from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|