| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD8a Molecule (CD8A) |
|---|
| Clone | 53-6-7 |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG2a |
|---|
| Format | phycoerythrin (PE) conjugate |
|---|
| Size | 0.1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FACS) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
|---|
| Immunogen | Mouse spleen cells |
|---|
| Other Names | cd8|LOC100136450|BB154331|Ly-2|Ly-35|Ly-B|Lyt-2|zgc:136643|CD8|Leu2|MAL|p32|RHACD8-4 |
|---|
| Gene, Accession # | Gene ID: 12525 |
|---|
| Catalog # | ABIN349711 |
|---|
| Price | |
|---|
| Order / More Info | CD8a Molecule (CD8A) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 16549792, 11805130, 15314695, 16785526, 398327, 6156984, 18263815, 1608966 |
|---|
| 产品资料 |
|
|