| 产品详情 |
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| Antigenic Specificity | ITGA5 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB, IHC, FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha 5 beta 1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc gamma R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues. |
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| Immunogen | Purified recombinant fragment of human ITGA5 expressed in E. Coli. |
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| Other Names | CD49e; FNRA; VLA5A; ITGA5 receptor subunit alpha Integrin alpha-F VLA-5 CD49e antigen; Integrin alpha-5; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e antigen; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; ITGA5; integrin; alpha 5 (fibronectin receptor; alpha polypeptide); CD49 antigen-like family member E |
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| Gene, Accession # | ITGA5, Gene ID: 3678, SwissProt: P08648 |
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| Catalog # | abx011678 |
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| Price | |
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| Order / More Info | ITGA5 Antibody from ABBEXA |
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| Product Specific References | n/a |
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