| 产品详情 |
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| Product Name | LEI-106 |
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| Description | Purity >98%. In humans, two forms of diacylglycerol lipase, DAGLAlpha and DAGLBeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG) by attacking DAG at the sn -1 position. LEI-106 is a potent in vitro inhibitor of sn -1 DAGLAlpha (IC50 = 18 nM). It blocks the hydrolysis of sn -1-oleoyl-2-AG, the natural substrate of DAGLAlpha, with a Ki value of 0.7 µM. LEI-106 inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in mouse brain membrane homogenates and in HEK293T cell membrane preparations (Ki = 0.8 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-glycine |
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| Gene, Accession, CAS # | CAS: 1620582-23-1 |
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| Catalog # | LS-H8447 |
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| Price | |
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| Order / More Info | LEI-106 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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