产品名称 Creatine Kinase, Brain (CKB) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2191989
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCreatine Kinase, Brain (CKB)
CloneCK-BYK-21E10
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b
Formatbiotin conjugate
Size50 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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DescriptionThe monoclonal antibody CK-BYK/21E10 recognizes human creatine kinase B-type, also known as CKB. Human CKB is a protein of 381 amino acids (~45 kDa), expressed in a number of tissues. CKB is most abundant in adult brain, approx. 5-fold lower in the stomach, 10-fold lower in the heart and barely detectable in liver. In brain, whereas most CKB has been shown to be cytosolic, several of the reactions requiring CKB are membrane-associated. CKB belongs to the creatine kinase (CK) isoenzymes that catalyse the synthesis of phosphocreatine (PCr) and its subsequent use in the regeneration of ATP in cell types where the consumption of ATP is rapid and/or sudden. In the brain the different CK isoforms constitute an energy shuttle wherein ATP produced in the mitochondria is used by a mitochondrial CK [e.g. ubiquitous mitochondrial creatine kinase (uMi-CK)] to generate PCr, which is then transported and used by a cytoplasmic CK [e.g. brain creatine kinase (CKB)] to regenerate ATP at discrete cellular sites of high ATP turnover. CKB appears to have a role in regenerating ATP needed for the transport of ions and neurotransmitters since CKB has been localized to brain synaptic plasma membranes, possibly coupled to Na+/K+-ATPase and acetylcholine receptor-rich membranes. Expression of CKB is developmentally controlled: in rat, brain CKB protein at birth is extremely low and increases 10-fold until week 4. This reflects the many energy-demanding processes in brain during brain development. Aliases Creatine kinase B chain, B-CK, BB-CK Immunogen Synthetic 17-mer peptide corresponding to the N-terminal sequence of human creatine kinase brain- type (SNSHNALKLRFPAEDEF)
Immunogenn/a
Other Namesbck|ckb|cb594|wu:fj36f10|wu:fj37d11|b-ck|ckbb|CKB|Chetk|Chkl|B-CK|CKBB|Bck|Ck-3|Ck3|Ckbb|Ckbr
Gene, Accession #Gene ID: 1152
Catalog #ABIN2191989
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Order / More InfoCreatine Kinase, Brain (CKB) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 7781040, 7776959
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