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| Product Name | Recombinant Escherichia coli LexA repressor (lexA) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 38.4kDa. Full Length: 1-202aa. N-terminal 6xHis-SUMO-tagged. Escherichia coli (strain K12). Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | lexA, UniProt: P0A7C2 |
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| Catalog # | RPC22797 |
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| Order / More Info | Recombinant Escherichia coli LexA repressor (lexA) from BIOMATIK |
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| Product Specific References | n/a |
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