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| Product Name | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 26.5kDa. Partial: 102-280aa. N-terminal 10xHis-tagged. Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CD95 ligand (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD_antigen: CD178) (CD95L) (FASL) (TNFSF6) |
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| Gene, Accession, CAS # | FASLG, UniProt: P63308 |
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| Catalog # | RPC26230 |
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| Order / More Info | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial from BIOMATIK |
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| Product Specific References | n/a |
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