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| Antigenic Specificity | AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a proline-rich domain and appears at about 40 kDa by SDS PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of the TOS motif in its structure in the same way as p70 S6 kinase and 4EP1 do as substrates of mTOR, then PRAS40 is phosphorylated by mTORC1 at Ser183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal transducing pathway through the mediation of not only PKB/Akt but also mTOR. Description: Serum. Synonyms: Polyclonal PRAS40 antibody, Anti-PRAS40 antibody, AKT1 Substrate 1 (Proline-rich) antibody, Lobe antibody, 40 kDa Proline-rich AKT Substrate 1 antibody. |
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| Immunogen | PRAS40 antibody was raised in rabbit using a synthetic peptide corresponding to the C terminal part of human PRAS40 (DLPRPRLNTSDFQKLKRKY) as the immunogenSerum |
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| Other Names | MGC81452|lobe|pras40|fb34a04|wu:fb34a04|Lobe|PRAS40|1110012J22Rik|AI227026|Lobel |
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| Gene, Accession # | Gene ID: 84335 |
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| Catalog # | ABIN927224 |
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| Price | |
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| Order / More Info | AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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