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| Product Name | Ciliary Neurotrophic Factor (CNTF) (AA 2-200) (Active) protein |
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| Description | Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor beta subunit, and a CNTF specific alpha receptor subunit. Upon binding to the CNTF, the beta subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE. Synonyms: Ciliary Neurotrophic Factor |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CNTF|HCNTF|AI429687|GPA |
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| Gene, Accession, CAS # | Gene ID: 1270 |
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| Catalog # | ABIN2017715 |
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| Order / More Info | Ciliary Neurotrophic Factor (CNTF) (AA 2-200) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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