| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | PDL1, Internal |
|---|
| Clone | polyclonal |
|---|
| Host Species | Goat |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | n/a |
|---|
| Format | immunoaffinity purified |
|---|
| Size | 100 µg |
|---|
| Concentration | 1.07 mg/ml |
|---|
| Applications | ELISA, Flow Cytometry, Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot. Anti-PDL-1 Antibody has been tested in Western Blot, ELISA, and IF. Positive control whole cell lysates used MDA-MB-231 p/n (W09-001-GK6) and A549 p/n (W09-001-372) and positive recombinant protein control for western blotting. Expect a band at ~33.3 kDa in western blot using appropriate lysates. Immunofluorescence positive control cell line used was MDA-MB-231 p/n (W09-001-GK6). Although not tested, this antibody is likely functional in flow cytometry and immunoprecipitation. |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | This affinity purified antibody is directed against human PDL1. This product was affinity purified from monospecific antiserum by immunoaffinity purification. Blast analysis of the sequence of the immunogen shows 100% identity with human. . PDL1 belongs to the immunoglobulin superfamily and BTN/MOG family. PDL1 is involved in the costimulatory signal, essential for T-cell proliferation and production of IL-10 and IFNG, in an IL-2 dependent and a PDCD1 independent manner. It is up-regulated in T-and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. PDL1 is up-regulated in B-cells activated by surface Ig cross-linking. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Anti-PDL-1 Antibody is useful for researches interested in cancer research, NF-kB pathway research, and the Immune system. |
|---|
| Immunogen | Anti-PDL1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human PDL1 conjugated to Keyhole Limpet Hemocyanin (KLH). |
|---|
| Other Names | Goat anti-PDL1 antibody, Programmed cell death 1 ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, PD-L1, PDCD1 ligand 1, B7-H1, B7 homolog 1, PDL-1, CD274 molecule antibody, MGC142294 antibody, PDL 1 |
|---|
| Gene, Accession # | CD274, Gene ID: 29126, UniProt: Q9NZQ7, NCBI: NP 001254635.1 |
|---|
| Catalog # | 600-101-GU8 |
|---|
| Price | |
|---|
| Order / More Info | PDL1, Internal Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|