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| Product Name | Recombinant Human Serine protease HTRA1 (HTRA1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 65kDa. Full Length of Mature Protein: 23-480aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Serine protease with a variety of targets, including Extracellular domain matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the Extracellular domain space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | High-temperature requirement A serine peptidase 1; L56; Serine protease 11 |
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| Gene, Accession, CAS # | HTRA1, UniProt: Q92743 |
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| Catalog # | RPC23345 |
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| Order / More Info | Recombinant Human Serine protease HTRA1 (HTRA1) from BIOMATIK |
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| Product Specific References | n/a |
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