产品名称 CD14 Molecule (CD14) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2192076
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCD14 Molecule (CD14)
Clone18D11
Host SpeciesMouse
Reactive Specieshuman
Isotypen/a
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsFlow Cytometry (FACS),Inhibition Assay (InhA)
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DescriptionThe monoclonal antibody 18D11 recognizes human monocyte marker CD14, a 53 kDa glycoprotein. CD14 is a glycophosphatidylinositol-linked protein, which is part of the LPS receptor complex. CD14 binds lipopolysaccharide (LPS) and as such, acts as a pattern recognition receptor (PRR). CD14 has also been suggested to mediate phagocytosis of bacteria an apoptotic cells. CD14 is involved in the endotoxin mediated release of Tumor Necrosis Factor-alpha by monocytic cells. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present at low density on a subpopulation granulocytes and activated or transformed B-cells. The monoclonal antibody 18D11 reacts with both soluble and membrane CD14. The monoclonal antibody 18D11 is useful for inhibition of biological activity of sCD14, it inhibits LPS induced TNF production. The monoclonal antibody is cross reactive with pig CD14. Together with a C5a neutralizing monoclonal antibody, 18D11 blocks sepsis in a pig model.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #ABIN2192076
Price
Order / More InfoCD14 Molecule (CD14) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 15576418, 11531018, 11254600
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