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| Product Name | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 23.8kDa. Full Length: 1-187aa. N-terminal 10xHis-tagged. Mus musculus (Mouse). Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Nip3 |
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| Gene, Accession, CAS # | Bnip3, UniProt: O55003 |
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| Catalog # | RPC26456 |
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| Order / More Info | Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) from BIOMATIK |
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| Product Specific References | n/a |
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