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| Product Name | Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 28.7kDa. Extracellular Domain: 58-273aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | C-type lectin domain family 8 member ALectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1Lectin-type oxidized LDL receptor 1 |
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| Gene, Accession, CAS # | OLR1, UniProt: P78380 |
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| Catalog # | RPC21770 |
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| Order / More Info | Recombinant Human Oxidized low-density lipoprotein receptor 1 (OLR1), partial from BIOMATIK |
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| Product Specific References | n/a |
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