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| Product Name | Recombinant Human PDGF-CC Protein |
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| Description | The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and -CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | Platelet-derived growth factor C;PDGF-C;Fallotein;Spinal cord-derived growth factor;SCDGF;VEGF-E;Platelet-derived growth factor C, latent form;PDGFC latent form;Platelet-derived growth factor C, receptor-binding form;PDGFC receptor-binding form;PDGFC;SCDGF;UNQ174/PRO200; |
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| Gene, Accession, CAS # | PDGFC, UniProt: Q9NRA1 |
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| Catalog # | PROTQ9NRA1-1 |
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| Price | |
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| Order / More Info | Recombinant Human PDGF-CC Protein from BOSTER BIO |
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| Product Specific References | n/a |
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