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| Product Name | Recombinant Human Caspase-3 |
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| Description | 29-175aa; Partial. MW: 20.7kD. Purity >90% as determined by SDS-PAGE. Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1] |
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| Gene, Accession, CAS # | CASP3, Gene ID: 836, Accession: NP_004337.2 |
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| Catalog # | MBS1265593 |
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| Order / More Info | Recombinant Human Caspase-3 from MYBIOSOURCE INC. |
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| Product Specific References | CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.Fernandes-Alnemri T., Litwack G., Alnemri E.S.J. Biol. Chem. 269:30761-30764(1994) Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.Tewari M., Quan L.T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D.R., Poirier G.G., Salvesen G.S., Dixit V.M.Cell 81:801- |
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