| 产品详情 |
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| Product Name | Recombinant Human Terminal nucleotidyltransferase 4A (TENT4B) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 67.3kDa. Full Length: 1-572aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Catalytic subunit of a TRAMP-like complex which has a poly RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | PAP-associated domain-containing protein 5 (Terminal nucleotidyltransferase 4B) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) (GLD4) (PAPD5) (TRF4-2) |
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| Gene, Accession, CAS # | TENT4B, UniProt: Q8NDF8 |
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| Catalog # | RPC26068 |
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| Order / More Info | Recombinant Human Terminal nucleotidyltransferase 4A (TENT4B) from BIOMATIK |
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| Product Specific References | n/a |
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