| 产品详情 |
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| Antigenic Specificity | LIMK2 (pT505) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IHC, IF/ICC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIMK2 (pT505) Antibody is a Rabbit Polyclonal antibody against LIMK2 (pT505). There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. |
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| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T505 of human LIMK2. |
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| Other Names | kinase LIMK2; LIM domain kinase 2; LIMK-2; LIMK2 |
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| Gene, Accession # | LIMK2, Gene ID: 3985, SwissProt: P53671 |
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| Catalog # | abx000435 |
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| Price | |
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| Order / More Info | LIMK2 (pT505) Antibody from ABBEXA |
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| Product Specific References | n/a |
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