Heavy-wall bottles are used in hybridization incubators or ovens with rotators.

An alternative to plastic bags or boxes, the membrane is rolled and placed into the bottle which is secured in a rotisserie. The membrane is saturated and drained during each revolution, resulting in even exposure of the blots to probe or wash solutions. Bottle fits most hybridization equipment and has straight interior walls for easy membrane placement and removal, as well as decanting of hybridization solutions.