JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Target |
JAK3 |
Reactivity |
Human, Mouse |
Host |
Mouse |
Clonality |
Monoclonal |
Tested Applications |
ELISA, WB, IF/ICC, FCM |
Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
Immunogen |
Purified recombinant fragment of human JAK3 expressed in E. Coli. |
Purification |
Unpurified Ascites. |
Isotype |
IgG1 |
Conjugation |
Unconjugated |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Molecular Weight |
125 kDa |
Swiss Prot |
P52333
|
GeneID |
3718
|
Enzyme Commission Number |
EC 2.7.10.2 |
Buffer |
Ascitic fluid containing 0.03% sodium azide. |
UNSPSC Code |
12352203 |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |