UPF1 Antibody is a Rabbit Polyclonal antibody against UPF1. Upf1 was identified as an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codonsUpf1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodiesUpf1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machineryTwo other active components of NMD, Upf2 and Upf3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.
| Target |
UPF1 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
A synthetic peptide of human UPF1. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
Q92900
|
| GeneID |
5976
|
| Gene Symbol |
UPF1 |
| Buffer |
PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |