Description

The anti-endocan monoclonal antibody MEP08 (LIA-0901BB) provides an analysis of endothelial activation status by immunohistochemistry.

The anti-endocan monoclonal antibody MEP08 (LIA-0901BB) can be kept for several weeks at 4 ° C and several months at -20 ° C.

The protocol is easily automated and provides highly reproducible results.

Characteristics

• Clone MEP08: Hybridoma cells producing the monoclonal antibody MEP08
• Isotype: mouse IgG2a/K
• Epitope: Internal Specificity : human, monkey, chicken
• Recommended for immunohistochemistry on paraffin sections or frozen sections
• Format: 1 tube / 50 µg
• Easy to use / do not require enzymatic treatment of cuts
• Conservation - 20 ° C

Documentation

• Datasheet
• Examples of protocols

• Bechard D, Meignin V, Scherpereel A, Oudin S, Kervoaze G, Bertheau P, Janin A, Tonnel A, Lassalle P Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. J Vasc Res. 2000 Sep-Oct;37(5):417-25.
• Ziol M, Sutton A, Calderaro J, Barget N, Aout M, Leroy V, Blanc JF, Sturm N, Bioulac-Sage P, Nahon P, Nault JC, Charnaux N, N'kontchou G, Trinchet JC, Delehedde M, Seror O, Beaugrand M, Vicaut E, Ganne-Carrié N. ESM-1 expression in stromal cells is predictive of recurrence after radiofrequency ablation in early hepatocellular carcinoma. J Hepatol. 2013 Dec;59(6):1264-70.
• Roudnicky F, Poyet C, Wild P, Krampitz S, Negrini F, Huggenberger R, Rogler A, Stöhr R, Hartmann A, Provenzano M, Otto VI, Detmar M. Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Cancer Res. 2013 Feb 1;73(3):1097-106.
• Cornelius A, Cortet-Rudelli C, Assaker R, Kerdraon O, Gevaert MH, Prévot V, Lassalle P, Trouillas J, Delehedde M, Maurage CA. Endothelial expression of endocan is strongly associated with tumor progression in pituitary adenoma. Brain Pathol. 2012 Nov;22(6):757-64.
• Leroy X, Aubert S, Zini L, Franquet H, Kervoaze G, Villers A, Delehedde M, Copin MC, Lassalle P. Vascular endocan (ESM-1) is markedly overexpressed in clear cell renal cell carcinoma. Histopathology. 2010 Jan;56(2):180-7.
• Maurage CA, Adam E, Minéo JF, Sarrazin S, Debunne M, Siminski RM, Baroncini M, Lassalle P, Blond S, Delehedde M. Endocan expression and localization in human glioblastomas. J Neuropathol Exp Neurol. 2009 Jun;68(6):633-41.
• Grigoriu BD, Depontieu F, Scherpereel A, Gourcerol D, Devos P, Ouatas T, Lafitte JJ, Copin MC, Tonnel AB, Lassalle P. Endocan expression and relationship with survival in human non-small cell lung cancer. Clin Cancer Res. 2006 Aug 1;12(15):4575-82.

Visit our webpages Clinicals Areas and Endocan