世联博研公司现货供应lktlabs品牌订货号为A044176的Abemaciclib

Description
Product Info
Shipping and Storage
Downloads
References
Custom Order

Description

Abemaciclib is a CDK4 and CDK6 inhibitor found to inhibit retinoblastoma phosphorylation, leading to G1/S arrest in ER+ breast cancer cells and to promote metabolic alterations in metastatic HR+ breast cancer cells.

Product Info

Cas No.	1231929-97-7
Purity	≥98%
Formula	C₂₇H₃₂F₂N₈
Formula Wt.	506.61
Chemical Name	N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
Synonym	LY2835219
Solubility	10 mM in DMSO; Soluble in dilute Acidic solution. Insoluble in Water

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A044176 MSDS PDF
Info Sheet	A044176 Info Sheet PDF

References

Torres-Guzman R, Calsina B, Hermoso A, et al. Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. Oncotarget. 2017 May 10. Epub ahead of print. PMID: 28537883

Tate SC, Burke TF, Hartman D, et al. Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours. Br J Cancer. 2016 Mar 15;114(6):669-679. PMID: 26978007

Knudsen ES, Hutcheson J, Vail P, et al. Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jun 10. Epub ahead of print. PMID: 28620137