Description
β Melanocyte-stimulating hormone (β MSH) is an endogenous POMC-derived peptide in the pituitary involved in energy homeostasis that activates melanocortin receptors. β MSH exhibits anti-inflammatory and anorexigenic activities. In vivo, β MSH decreases the intensity of acetaminophen-induced liver lesions. In other animal models, this peptide increases orexin and corticotropin-releasing factor (CRF) levels and decreases food intake.
References
Blagaić V, Houra K, Turcić P, et al. The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Molecules. 2010 Mar 3;15(3):1232-41. PMID: 20335976.
Kamisoyama H, Honda K, Saneyasu T, et al. Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks. Neurosci Lett. 2009 Jul 24;458(3):102-5. PMID: 19393716.