Description
Tyrosinase (369-377) is a tumor antigenic peptide produced by the proteasome that has been used to develop tumor-targeted vaccines with mixed efficacy.
References
Guillaume B, Stroobant V, Bousquet-Dubouch MP, et al. Analysis of the processing of seven human tumor antigens by intermediate proteasomes. J Immunol. 2012 Oct 1;189(7):3538-47. PMID: 22925930.
Mitchell MS, Darrah D, Yeung D, et al. Phase I trial of adoptive immunotherapy with cytolytic T lymphocytes immunized against a tyrosinase epitope. J Clin Oncol. 2002 Feb 15;20(4):1075-86. PMID: 11844833.