Description
A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.
References
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Wang H, Liu S, Wang Y, et al. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016 Jan 14;16(2):126-131. PMID: 26773180.
Nishino Y, Murakami M, Funaba M. Expression and role of the TGF-beta family in glial cells infected with Borna disease virus. Microbes Infect. 2016 Feb;18(2):128-136. PMID: 26482505.
Ho YS, Tsai WH, Lin FC, et al. Cardioprotective actions of TGFbetaRI inhibition through stimulating autocrine/paracrine of survivin and inhibiting Wnt in cardiac progenitors. Stem Cells. 2016 Feb;34(2):445-455. PMID: 26418219.
Sun X, Kim YH, Phan TN, et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem. 2014;78(11):1805-1812. PMID: 25351330.
Nishino Y
