| 产品名称 | (R,S)-AM 1241 - LKT Labs | |||||||||||||||||||||||||||||||
| 产品货号 | A480020 | |||||||||||||||||||||||||||||||
| 产品价格 | 现货询价，电话：010-67529703 | |||||||||||||||||||||||||||||||
| 产品规格 | 1 mg 5 mg 25 mg | |||||||||||||||||||||||||||||||
| 产品品牌 | lktlabs | |||||||||||||||||||||||||||||||
| 产品概述 | ||||||||||||||||||||||||||||||||
| 产品详情 |  (R,S)-AM 1241Product ID A480020 Cas No. 444912-48-5 Purity ≥97%
DescriptionAM1241 is a selective cannabinoid receptor 2 (CB2) agonist. It demonstrates activity in multiple pain murine models. AM1241 was used to treat osteopathic carcinoma pain in mice. AM1241 decreased allodynia found in a rodent model, and also decreased thermal hyperalgesia. AM1241 was used in a murine Parkinson’s disease model, where it increased expression of Parkin and PINK1, and also stimulated neurogenesis. Product Info
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ReferencesShi J, Cai Q, Zhang J et al. AM1241 alleviates MPTP-induced Parkinsons’s disease and promotes the regeneration of DA neurons in PD mice. Oncotarget. 2017 Jun 29;8(40):67837-67850. PMID: 28978077. Curto-Reyes V, Llames S, Hidalgo A et al. Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. Br J Pharmacol. 2010 Jun;160(3):561-73. PMID: 20233215. Ibrahim MM, Deng H, Zvonok A et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci USA. 2003 Sep 2;100(18):10529-33. PMID: 12917492. |
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