Description
(-)-Epicatechin gallate (ECG) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, anticancer, and anti-inflammatory activities. ECG displays agonist activity at cannabinoid 1 (CB1) receptors. ECG also inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In vitro, this compound inhibits LPS- or peptidoglycan-induced production of VEGF and expression of COX-2.
References
Nakanishi T, Mukai K, Hosokawa Y, et al. Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells. Int Endod J. 2014 May 21. [Epub ahead of print]. PMID: 24847951.
Ly BT, Chi HT, Yamagishi M, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One. 2013 Jun 20;8(6):e66378. PMID: 23840454.
Korte G, Dreiseitel A, Schreier P, et al. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010 Jan;17(1):19-22. PMID: 19897346.
