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产品名称 (+)-Bicuculline - LKT Labs
产品货号 B3211
产品价格 现货询价，电话：010-67529703
产品规格 25 mg 100 mg 500 mg
产品品牌 lktlabs
产品概述
产品详情 (+)-Bicuculline (+)-Bicuculline
Product ID B3211
Cas No. 485-49-4
Purity ≥98%
Unit SizeCostQuantityStock
25 mg $57.10 In stock
100 mg $107.00 In stock
500 mg $392.40 Please Inquire
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Description

Bicuculline is a neuromodulatory GABA-A receptor antagonist used to study regional variation of GABA receptors and the role of GABA-A receptors in motor disorders, pain, seizure, nociception, anxiety, and memory. Through its inhibition of GABA-A receptors, bicuculline potentiates activation at NMDA receptors and produces membrane depolarization, inhibiting K+ conductance and prolonging Ca2+-dependent action potentials in neurons. Specific rotation +130 (20 D, chloroform c=2)

Product Info

Cas No.

485-49-4

Purity

≥98%

Formula

C20H17NO6

Formula Wt.

367.35

IUPAC Name

(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4, 5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B3211 MSDS PDF

Info Sheet

B3211 Info Sheet PDF

References

Dela Peña IJ, Lee HL, Yoon SY, et al. The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABA(A) receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice. Drug Discov Ther. 2013 Feb;7(1):18-23. PMID: 23524939.

Torkaman-Boutorabi A, Soltani S, Oryan S, et al. Involvement of the dorsal hippocampal GABA-A receptors in histamine-induced facilitation of memory in the Morris water maze. Pharmacol Biochem Behav. 2013 Apr;105:142-50. PMID: 23438692.

Ionov ID, Roslavtseva LA. Coadministration of bicuculline and NMDA induces paraplegia in the rat. Brain Res. 2012 Apr 27;1451:27-33. PMID: 22445063

Ji G, Neugebauer V. Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol. 2011 Nov;106(5):2642-52. PMID: 21880942.

Costa LG, Doctor SV, Murphy SD. Antinociceptive and hypothermic effects of trimethyltin. Life Sci. 1982 Sep 13;31(11):1093-102. PMID: 6890611.

Heyer EJ, Nowak LM, Macdonald RL. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. PMID: 7055710.
产品资料