| 产品名称 | MITF antibody | anti MITF antibody | Biorbyt |
| 产品货号 | orb534746 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | Biorbyt |
| 产品概述 | |
| 产品详情 | |
| Product Name | MITF antibody |
|---|---|
| Catalog Number | orb534746 |
| Species/Host | Rabbit |
| Reactivity | Canine, Human |
| Conjugation | Unconjugated |
| Tested applications | FACS, IF, IHC-P |
| Immunogen | Recombinant full-length human MiTF protein |
| Target | MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi. |
| Form/Appearance | 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Monoclonal |
| Purity | Purified Ab with BSA and Azide at 200ug/ml |
| MW | 52-56 kDa |
| Clone ID | MITF/2987R |
| Uniprot ID | O75030 |
| Entrez | 4286 |
| Dilution Range | FACS: 0.5-1 μg/million cells, IHC-P: 0.5-1.0 μg/ml for 30 minutes at RT, IF: 0.5-1 μg/ml |
| 产品资料 |