| 产品名称 | IVL antibody | anti IVL antibody | Biorbyt |
| 产品货号 | orb534707 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | Biorbyt |
| 产品概述 | |
| 产品详情 | |
| Product Name | IVL antibody |
|---|---|
| Catalog Number | orb534707 |
| Species/Host | Rabbit |
| Reactivity | Aves, Canine, Human, Monkey, Porcine, Primate |
| Conjugation | Unconjugated |
| Tested applications | FACS, IF, IHC-P |
| Immunogen | Recombinant full-length human IVL protein |
| Target | It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix. |
| Form/Appearance | 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Monoclonal |
| Purity | Purified Ab with BSA and Azide at 200ug/ml |
| MW | 66-170 kDa |
| Clone ID | IVRN/2113R |
| Uniprot ID | P07476 |
| Entrez | 3713 |
| Dilution Range | FACS: 0.5-1 μg/million cells , IF: 1-2 μg/ml , IHC-P: 0.1-0.2 μg/ml for 30 min at RT |
| 产品资料 |