产品名称 Acetylshikonin | Biorbyt
产品货号 orb390014
产品价格 现货询价,电话:010-67529703
产品规格
产品品牌 Biorbyt
产品概述
产品详情
Product Name Acetylshikonin
Catalog Number orb390014
Conjugation Unconjugated
Hazard Information Non-Toxic
Target Acetylshikonin
Form/Appearance Powder
Storage Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months at 2-8°C.
Note For research use only.
Purity >98%
Formula C18H18O6
MW 330.33
CAS Number [54984-93-9]
Source The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
Activity 1. Acetylshikonin (ASK), a derivate of shikonin, can effectively inhibit tumor cells.
2. Acetylshikonin can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus.
3. Acetylshikonin exhibits the most potent antiapoptosis activity through the inhibition of the generation of reactive oxygen species as well as protection of the loss of mitochondria membrane potential.
4. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
Application Notes Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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