| 产品名称 |
Imatinib, Methanesulfonate Salt |
| 产品货号 |
orb61045 |
| 产品价格 |
现货询价，电话：010-67529703
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| 产品规格 |
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| 产品品牌 |
Biorbyt |
| 产品概述 |
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| 产品详情 |
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| Product Name | Imatinib, Methanesulfonate Salt |
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| Catalog Number | orb61045 |
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| Conjugation | Unconjugated |
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| Hazard Information | Non-Toxic |
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| Target | Imatinib, Methanesulfonate Salt |
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| Alternative Names | (click to expand) Glivec, CGP-57148B, STI-571 |
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| Form/Appearance | White crystalline powder |
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| Storage | Store at or below -20°C. |
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| Note | For research use only. |
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| Purity | >99% pure |
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| Formula | C29H31N7O·CH4SO3 |
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| MW | 589.71 g/mol |
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| CAS Number | [220127-57-1] |
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| Chemical Name | methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide |
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| PubChem CID | CID 123596 |
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| Application Notes | In vitro: In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively.Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR.Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively.A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis.
In vivo: Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth.In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. |
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| In vitro | | DMSO | 200 mM | | Alcohol | Ethanol (<1mM) | | Water | 200 mM |
| 产品资料 |
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