| 产品名称 | Fibrinogen antibody | Biorbyt |
| 产品货号 | orb303373 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | Biorbyt |
| 产品概述 | |
| 产品详情 | |
| Product Name | Fibrinogen antibody |
|---|---|
| Catalog Number | orb303373 |
| Species/Host | Gallus |
| Conjugation | Unconjugated |
| Tested applications | FACS |
| Immunogen | Purified full length native protein |
| Target | Fibrinogen |
| Form/Appearance | Liquid |
| Storage | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Note | For research use only. |
| Isotype | IgY |
| Clonality | Polyclonal |
| Purity | 0.15M sodium chloride, 0.02M sodium phosphate, 0.1 % sodium azide, pH 7.2 |
| MW | 24 kDa |
| Uniprot ID | Q9UE34 |
| Dilution Range | FACS: 1: 10 |
| Application Notes | Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989). |
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