| 产品名称 |
MTAP antibody | anti MTAP antibody | Biorbyt |
| 产品货号 |
orb534762 |
| 产品价格 |
现货询价，电话：010-67529703
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| 产品规格 |
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| 产品品牌 |
Biorbyt |
| 产品概述 |
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| 产品详情 |
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| Product Name | MTAP antibody |
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| Catalog Number | orb534762 |
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| Species/Host | Rabbit |
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| Reactivity | Human |
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| Conjugation | Unconjugated |
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| Tested applications | ELISA, IHC-P, WB |
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| Immunogen | Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary) |
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| Target | Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway. |
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| Form/Appearance | 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
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| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. |
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| Note | For research use only. |
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| Isotype | IgG |
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| Clonality | Monoclonal |
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| Purity | Purified Ab with BSA and Azide at 200ug/ml |
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| MW | 31 kDa |
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| Clone ID | MTAP/3137R |
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| Uniprot ID | Q13126 |
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| Entrez | 4507 |
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| Dilution Range | ELISA: 2-4 μg/ml, WB: 0.5-2 μg/ml, IHC-P: 1-2 μg/ml for 30 minutes at RT |
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| 产品资料 |
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