| 产品名称 |
MUC1 antibody | anti MUC1 antibody | Biorbyt |
| 产品货号 |
orb534768 |
| 产品价格 |
现货询价，电话：010-67529703
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| 产品规格 |
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| 产品品牌 |
Biorbyt |
| 产品概述 |
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| 产品详情 |
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| Product Name | MUC1 antibody |
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| Catalog Number | orb534768 |
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| Species/Host | Rabbit |
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| Reactivity | Human, Mouse |
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| Conjugation | Unconjugated |
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| Tested applications | ELISA, IHC-P |
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| Immunogen | Human milk-fat globule membranes (HMFGM) |
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| Target | This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in > 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver. |
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| Form/Appearance | 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
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| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. |
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| Note | For research use only. |
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| Isotype | IgG |
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| Clonality | Monoclonal |
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| Purity | Purified Ab with BSA and Azide at 200ug/ml |
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| MW | 265-400 kDa |
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| Clone ID | MUC1/2818R |
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| Uniprot ID | P15941 |
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| Entrez | 4582 |
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| Dilution Range | ELISA: 2-5 μg/ml, IHC-P: 0.25-0.5 μg/ml for 30 minutes at RT |
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| 产品资料 |
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