| 产品名称 |
CD163 antibody | anti CD163 antibody | Biorbyt |
| 产品货号 |
orb535004 |
| 产品价格 |
现货询价，电话：010-67529703
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| 产品规格 |
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| 产品品牌 |
Biorbyt |
| 产品概述 |
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| 产品详情 |
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| Product Name | CD163 antibody |
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| Catalog Number | orb535004 |
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| Species/Host | Mouse |
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| Reactivity | Human |
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| Conjugation | Unconjugated |
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| Tested applications | IHC-P |
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| Immunogen | Recombinant fragment of human CD163 protein (around aa 43-196) (exact sequence is proprietary) |
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| Target | This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
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| Form/Appearance | 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
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| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. |
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| Note | For research use only. |
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| Isotype | IgG2b, kappa |
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| Clonality | Monoclonal |
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| Purity | Purified Ab with BSA and Azide at 200ug/ml |
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| MW | 140 kDa |
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| Clone ID | M130/2164 |
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| Uniprot ID | Q86VB7 |
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| Entrez | 9332 |
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| Dilution Range | IHC-P: 1-2 μg/ml for 30 minutes at RT |
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| 产品资料 |
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