| 产品名称 | Corosolic acid | Biorbyt |
| 产品货号 | orb389985 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | Biorbyt |
| 产品概述 | |
| 产品详情 | |
| Product Name | Corosolic acid |
|---|---|
| Catalog Number | orb389985 |
| Conjugation | Unconjugated |
| Hazard Information | Non-Toxic |
| Target | Corosolic acid |
| Form/Appearance | Powder |
| Storage | Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months at 2-8°C. |
| Note | For research use only. |
| Purity | >98% |
| Formula | C30H48O4 |
| MW | 472.7 |
| CAS Number | [4547-24-4] |
| Source | The barks of Lagerstroemia speciosa |
| Activity | 1. Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities, it can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats, suggests CRA can be beneficial for preventing atherosclerosis-related diseases. 2. Corosolic acid significantly inhibits cell viability in both a dose- and a time-dependent manner, induces apoptosis is associated with the activation of caspases via a mitochondrial pathway, suggests it could have strong potentials for clinical application in treating human cervix adenocarcinoma and improving cancer chemotherapy. 3. Corosolic acid can suppress the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-kappaB activation, thus, it might be a potential new tool for tumor prevention and therapy. 4. Corosolic acid has antidiabetic effects(especially type 2 diabetes), can improve glucose metabolism by reducing insulin resistance, it inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. 5. Corosolic acid has antitumor effects in murine sarcoma model through significantly impairing subcutaneous tumor development and lung metastasis and targeting the immunosuppressive activity of myeloid-derived suppressor cells (MDSC), and can enhance the antitumor effects of adriamycin and cisplatin in in vitro. |
| Application Notes | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| 产品资料 |